James H Segars Selected Research

Neoplasms (Cancer)

1/2021	Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids.
11/2020	Simvastatin ameliorates altered mechanotransduction in uterine leiomyoma cells.
2/2017	Dietary phytochemicals for possible preventive and therapeutic option of uterine fibroids: Signaling pathways as target.
1/2015	Gonadotropin surge-inhibiting/attenuating factors: a review of current evidence, potential applications, and future directions for research.
8/2014	Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: promising options for prevention and treatment of uterine fibroids?
12/2009	Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas.
10/2007	Compensatory alterations in energy homeostasis characterized in uterine tumors from hereditary leiomyomatosis and renal cell cancer.
7/2004	Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids.
12/2003	New potential regulators of uterine leiomyomata from DNA arrays: the ionotropic glutamate receptor GluR2.

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James H Segars Research Topics

Disease

37	Leiomyoma (Uterine Fibroids) 03/2024 - 08/2003
9	Neoplasms (Cancer) 01/2021 - 12/2003
7	Infertility (Sterility) 01/2024 - 12/2012
4	Inflammation (Inflammations) 06/2021 - 02/2009
4	Fibrosis (Cirrhosis) 01/2021 - 01/2014
3	Ovarian Hyperstimulation Syndrome 09/2012 - 01/2006
2	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2015 - 11/2010
2	Infections 01/2014 - 02/2005
2	Obesity 12/2011 - 11/2010
1	Autoimmune oophoritis 07/2023
1	Endometriosis 01/2022
1	Female Genital Diseases 12/2021
1	Hyperlipidemias (Hyperlipidemia) 10/2021
1	Respiratory Insufficiency (Respiratory Failure) 06/2021
1	COVID-19 06/2021
1	Communicable Diseases (Infectious Diseases) 06/2021
1	Sepsis (Septicemia) 06/2021
1	Human Influenza (Influenza) 06/2021
1	Virus Diseases (Viral Diseases) 06/2021
1	Pneumonia (Pneumonitis) 06/2021
1	Amenorrhea 01/2018
1	Hypertension (High Blood Pressure) 01/2018
1	Pre-Eclampsia (Preeclampsia) 01/2017
1	Fetal Growth Retardation (Intrauterine Growth Retardation) 03/2016
1	Fetal Death 03/2016
1	Infarction (Infarctions) 03/2016
1	Vitamin D Deficiency 03/2015
1	Metabolic Diseases (Metabolic Disease) 01/2015
1	Leiomyosarcoma 01/2015

Drug/Important Bio-Agent (IBA)

9	CollagenIBA 01/2023 - 07/2004
9	Proteins (Proteins, Gene)FDA Link 01/2023 - 08/2003
7	Messenger RNA (mRNA)IBA 01/2023 - 08/2003
5	Hormones (Hormone)IBA 01/2024 - 11/2010
5	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2024 - 01/2006
3	Progesterone Receptors (Progesterone Receptor)IBA 12/2021 - 01/2018
3	Progesterone FDA LinkGeneric 01/2021 - 12/2012
3	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2021 - 12/2003
3	Vitamin D FDA LinkGeneric 01/2021 - 03/2015
3	PhytochemicalsIBA 11/2017 - 08/2014
3	Estradiol (Delestrogen)FDA LinkGeneric 09/2012 - 12/2003
2	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 01/2024 - 01/2023
2	TeaIBA 01/2024 - 01/2023
2	Estrogens (Estrogen)FDA Link 10/2021 - 07/2004
2	SteroidsIBA 10/2021 - 06/2021
2	Simvastatin (Zocor)FDA LinkGeneric 10/2021 - 11/2020
2	Collagenases (Collagenase)FDA Link 01/2021 - 01/2021
2	A Kinase Anchor ProteinsIBA 01/2021 - 01/2019
2	LigandsIBA 01/2021 - 01/2019
2	ulipristal acetate FDA Link 01/2019 - 01/2018
2	Pravastatin (Pravachol)FDA LinkGeneric 01/2017 - 03/2016
2	Transforming Growth Factor beta (TGF-beta)IBA 12/2009 - 08/2006
2	Transforming Growth Factor beta3 (TGF beta 3)IBA 12/2009 - 07/2004
2	Leuprolide (Lupron)FDA LinkGeneric 11/2006 - 01/2006
2	ganirelix FDA Link 11/2006 - 01/2006
1	GonadotropinsIBA 01/2024
1	Oral ContraceptivesIBA 01/2024
1	Propranolol (Inderal)FDA LinkGeneric 08/2023
1	Metoprolol (Toprol-XL)FDA LinkGeneric 08/2023
1	AntioxidantsIBA 01/2023
1	Plasminogen Activators (Plasminogen Activator)IBA 01/2023
1	Cyclin D1IBA 01/2023
1	Fibronectins (Fibronectin)IBA 01/2023
1	Investigational DrugsIBA 01/2023
1	elagolixIBA 01/2022
1	Androgen Receptors (Androgen Receptor)IBA 12/2021
1	Dexamethasone (Maxidex)FDA LinkGeneric 06/2021
1	GlucocorticoidsIBA 06/2021
1	nintedanibIBA 01/2021
1	Ramipril (Altace)FDA LinkGeneric 01/2021
1	activin AIBA 01/2021
1	Quinapril (Accupril)FDA LinkGeneric 01/2021
1	progesterone receptor BIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Angiotensin IIIBA 01/2021
1	Progestins (Progestagens)IBA 01/2021
1	Nuclear Antigens (Extractable Nuclear Antigens)IBA 01/2021
1	Lisinopril (Prinivil)FDA LinkGeneric 01/2021
1	TransferasesIBA 01/2021
1	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2021
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2021
1	Microbial Collagenase (Clostridiopeptidase A)FDA Link 01/2021
1	Calcitriol (Calcijex)FDA LinkGeneric 01/2021
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021
1	Verteporfin (Visudyne)FDA Link 01/2021
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2021
1	rhoA GTP-Binding ProteinIBA 11/2020
1	Collagen Type I (Type I Collagen)IBA 11/2020
1	IntegrinsIBA 11/2020
1	LuciferasesIBA 01/2019
1	ulipristalIBA 01/2018
1	CreatinineIBA 01/2018
1	CateninsIBA 02/2017
1	FibrinIBA 03/2016

Therapy/Procedure

14	Therapeutics 01/2024 - 10/2006
5	Hysterectomy 01/2021 - 08/2003
2	Aftercare (After-Treatment) 03/2024 - 11/2020
2	Transplantation 01/2021 - 06/2017
1	Injections 01/2021
1	Minimally Invasive Surgical Procedures 01/2015
1	Contraception (Birth Control) 01/2015